Atrial Fibrillation Research
Search our entire network:
J Interv Card Electrophysiol (2002)
Dilatation as a marker of pulmonary veins initiating atrial fibrillation.
T Yamane, DC Shah, P Jaïs, M Hocini, JT Peng, I Deisenhofer, J Clémenty, M Haïssaguerre
BACKGROUND:The pulmonary veins (PVs) have been shown to trigger paroxysmal atrial fibrillation. The relationship of anatomical dimensions versus arrhythmogenicity has not been assessed. METHODS: The diameters of four PVs were measured by selective PV angiography before ablation in 39 consecutive patients (23 male, mean age 46 years) with only one (25 patients) or two (14 patients) arrhythmogenic PVs (ArPVs). After ablation of ArPVs, no patient had recurrence of atrial fibrillation from the remaining PVs. Comparisons were performed variously between ArPV and non-ArPV, and within and across both groups. RESULTS: ArPVs were distributed as follows; left superior PV: 40%, left inferior PV: 28%, right superior PV: 26%, and right inferior PV: 6%. Statistical comparisons showed that (1) Triggers of atrial fibrillation were located in the largest PV in 72% of patients, (2) For each PV, the mean diameter of ArPV was significantly larger than that of non-ArPV (p < 0.05), (3) No significant difference was observed in the diameter of the four different ArPVs (range 16.2 +/- 1.3 to 17.2 +/- 4.4). CONCLUSIONS: In patients with atrial fibrillation initiated from one or two ArPVs, the diameters of ArPVs were significantly larger than those of non-ArPVs irrespective of the specific PV concerned, which might imply a possible role of PV dilatation in the arrhythmogenesis.
[Pubmed Record - new window] | [Full Text - new window]
Browse articles via key phrases:
atrial fibrillation, ArPV, ArPVs, ablation, CONCLUSIONS:, PV dilatation, non-ArPV, imply, atrial fibrillation initiated, largest PV, PV, non-ArPVs irrespective, follows; left, PVs, METHODS:, arrhythmogenicity, selective PV angiography, variously, background:the pulmonary veins pvs, RESULTS: ArPVs, 1 triggers,Related Articles:
- Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonar
N Engl J Med Sep 03, 1998
... . During a follow-up period of 8+/-6 months after ablation, 28 patients (62 percent) had no recurrence of atrial fibrillation. CONCLUSIONS: The pulmonary veins are an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation. ... - Initiation of atrial fibrillation by ectopic beats originating from the pulmonar
Circulation Nov 18, 1999
BACKGROUND:Atrial fibrillation (AF) can be initiated by ectopic beats originating from the atrial or great venous tissues. This study investigated the anatomic characteristics and electrophysiological properties of pulmonary veins (PVs), as well as the ... - Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.
Stroke Sep 12, 1991
... 80-89 years. While these findings highlight the impact of each cardiovascular condition on the risk of stroke, the data suggest that the elderly are particularly vulnerable to stroke when atrial fibrillation is present.(ABSTRACT TRUNCATED AT 250 WORDS) - A comparison of rate control and rhythm control in patients with atrial fibrilla
N Engl J Med Dec 05, 2002
... and treatment with antiarrhythmic drugs to maintain sinus rhythm, and the other is the use of rate-controlling drugs, allowing atrial fibrillation to persist. In both approaches, the use of anticoagulant drugs is recommended. METHODS: We conducted a ... - Rhythm or rate control in atrial fibrillation--Pharmacological Intervention in Atrial Fibr
Lancet Dec 14, 2000
... 17 [14%] in group A, p=0.036). INTERPRETATION: With respect to symptomatic improvement in patients with atrial fibrillation, the therapeutic strategies of rate versus rhythm control yielded similar clinical results overall. However, exercise tolerance is ... - Catheter-induced linear lesions in the left atrium in patients with atrial fibrillation: a
J Am Coll Cardiol Oct 02, 2003
... current and the electroanatomic mapping system CARTO, four line designs were tested in 84 patients suffering from drug-refractory atrial fibrillation (AFib). BACKGROUND: Prevention of AFib by trigger elimination within the pulmonary veins (PVs) has been ... - Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-anal
Ann Intern Med Sep 28, 1999
... randomized comparisons yielded inconclusive results. CONCLUSIONS: Adjusted-dose warfarin and aspirin reduce stroke in patients with atrial fibrillation, and warfarin is substantially more efficacious than aspirin. The benefit of antithrombotic therapy was ... - Electrophysiological end point for catheter ablation of atrial fibrillation initiated from
Circulation Apr 26, 2000
BACKGROUND: The end point for catheter ablation of pulmonary vein (PV) foci initiating atrial fibrillation (AF) has not been determined. METHODS AND RESULTS: Ninety patients underwent mapping during spontaneous or induced ectopy and/or AF initiation. ... - Circular mapping and ablation of the pulmonary vein for treatment of atrial fibrillation:
J Am Coll Cardiol Jul 26, 2002
... versus ostial pulmonary veins (PV) isolation using the circular mapping technique. BACKGROUND: Electrical isolation of the PVs in patients with atrial fibrillation (AF) remains a technical challenge. METHODS: Two hundred eleven patients (163 men; mean age ... - Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation.
N Engl J Med Jun 22, 2006
... in atrial myocytes and mediates the coordinated electrical activation of the atria. We hypothesized that idiopathic atrial fibrillation has a genetic basis and that tissue-specific mutations in GJA5, the gene encoding connexin 40, may predispose the atria ... - Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm ma
JAMA May 09, 2001
... : Cross-sectional study of adults aged 20 years or older who were enrolled in a large health maintenance organization in California and who had atrial fibrillation diagnosed between July 1, 1996, and December 31, 1997. MAIN OUTCOME MEASURES: Prevalence of ... - Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrilla
N Engl J Med Mar 30, 2000
... who were assigned to amiodarone (35 percent) and 127 of those who were assigned to sotalol or propafenone (63 percent) had a recurrence of atrial fibrillation (P<0.001). Adverse events requiring the discontinuation of drug therapy occurred in 18 percent ... - KCNQ1 gain-of-function mutation in familial atrial fibrillation.
Science Jan 10, 2003
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood. We studied a family with hereditary persistent AF and identified the causative mutation (S140G) in the KCNQ1 (KvLQT1) gene on chromosome 11p15.5. The ... - Effect of dronedarone on cardiovascular events in atrial fibrillation.
N Engl J Med Feb 13, 2009
... a multicenter trial to evaluate the use of dronedarone in 4628 patients with atrial fibrillation who had additional risk factors for death. Patients were randomly assigned to receive dronedarone, 400 mg twice a day, or placebo. The primary outcome was the ... - Valsartan for prevention of recurrent atrial fibrillation.
N Engl J Med Apr 16, 2009
... interval [CI], 0.83 to 1.14; P=0.73). More than one episode of atrial fibrillation occurred in 194 of 722 patients (26.9%) in the valsartan group and in 201 of 720 (27.9%) in the placebo group (adjusted odds ratio, 0.89; 99% ... - Impact of atrial fibrillation on the risk of death: the Framingham Heart Study.
Circulation Sep 25, 1998
BACKGROUND: Atrial fibrillation (AF) causes substantial morbidity. It is uncertain whether AF is associated with excess mortality independent of associated cardiac conditions and risk factors. METHODS AND RESULTS: We examined the mortality of subjects 55 ... - Pulmonary-vein isolation for atrial fibrillation in patients with heart failure.
N Engl J Med Oct 23, 2008
... were monitored for both symptomatic and asymptomatic episodes of atrial fibrillation. RESULTS: In all, 41 patients underwent pulmonary-vein isolation, and 40 underwent atrioventricular-node ablation with biventricular pacing; none were lost to follow-up ... - Exercise intolerance in patients with atrial fibrillation: clinical and echocardiographic
J Am Soc Echocardiogr Dec 26, 2005
... exercise intolerance is a major symptom of patients with atrial fibrillation (AF), the factors limiting these patients' exercise capacity remains uncertain. This study evaluated the correlation of clinical and echocardiographic parameters with exercise ... - Lenient versus Strict Rate Control in Patients with Atrial Fibrillation.
N Engl J Med Mar 16, 2010
... 2]; P<0.001). The frequencies of symptoms and adverse events were similar in the two groups. CONCLUSIONS: In patients with permanent atrial fibrillation, lenient rate control is as effective as strict rate control and is easier to achieve. (ClinicalTrials ... - Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation.
N Engl J Med Jul 10, 2008
Atrial fibrillation is a common arrhythmia that is hereditary in a small subgroup of patients. In a family with 11 clinically affected members, we mapped an atrial fibrillation locus to chromosome 1p36-p35 and identified a heterozygous frameshift mutation ... - Rhythm control versus rate control for atrial fibrillation and heart failure.
N Engl J Med Jun 20, 2008
... ejection fraction of 35% or less, symptoms of congestive heart failure, and a history of atrial fibrillation. The primary outcome was the time to death from cardiovascular causes. RESULTS: A total of 1376 patients were enrolled (682 in the rhythm-control ...
